lupus

Promising Screening Tools Assessed for Cognitive Dysfunction in SLE

Promising Screening Tools Assessed for Cognitive Dysfunction in SLE

The Montreal Cognitive Assessment (MoCA) questionnaire is an easy-to-administer, inexpensive, effective screening tool that can identify patients with systemic lupus erythematosus (SLE) who might be at risk for cognitive dysfunction (CD) and might benefit from additional neuropsychiatric assessment, according to data published in Lupus.

Recurrent lupus nephritis less frequent after kidney transplant

Recurrent lupus nephritis less frequent after kidney transplant

Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.

Naturally Produced Fat Molecules Could Help Treat Lupus

Naturally Produced Fat Molecules Could Help Treat Lupus

Nitro-fatty acids — a type of fatty molecule naturally produced in the body — could act as natural inhibitors of the stimulator of IFN genes (STING), a protein involved in inflammatory diseases such as systemic lupus erythematosus (SLE), according to a study.

The study, “Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling,” was published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

Organs are not just bystanders, may be active participants in fighting autoimmune disease

Organs are not just bystanders, may be active participants in fighting autoimmune disease

Organs affected by autoimmune disease could be fighting back by "exhausting" immune cells that cause damage using methods similar to those used by cancer cells to escape detection, according to a study by researchers at the University of Pittsburgh School of Medicine published today in the Journal of Clinical Investigation.

Ustekinumab: a promising new drug for SLE?

Ustekinumab: a promising new drug for SLE?

In The Lancet, Ronald van Vollenhoven and colleagues report a positive multicentre double-blind phase 2 randomised, placebo-controlled trial with ustekinumab, an anti-interleukin-12/23 (IL-12/23) monoclonal antibody, in 102 patients aged 18–75 years with active systemic lupus erythematosus (93 women and nine men).

Heart Disease Less Likely in Lupus Patients in Remission for 5 or More Years

Heart Disease Less Likely in Lupus Patients in Remission for 5 or More Years

Patients with systemic lupus erythematosus in remission for five or more years are at a lower risk of cardiovascular disease than those with shorter remission times or who fail to enter remission, a retrospective study reports.

The study, “Prolonged remission is associated with a reduced risk of cardiovascular disease in patients with systemic lupus erythematosus: a GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study,” was published in Clinical Rheumatology.

Transplantation of Placenta Cells May Halt Inflammation in Lupus Patients

Transplantation of Placenta Cells May Halt Inflammation in Lupus Patients

The transplantation of human placental cells was found to suppress immune and inflammatory responses in a mouse model of systemic lupus erythematosus (SLE), suggesting a potential new therapeutic strategy for lupus, a study shows.

The study, “Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto’s thyroiditis and Systemic lupus erythematosus,” was published in the journal Cytotherapy.

Study suggests Virgin Olive Oil May Help Reduce SLE Activity

Study suggests Virgin Olive Oil May Help Reduce SLE Activity

Virgin olive oil, especially its phenol components, showed anti-inflammatory properties in mice with systemic lupus erythematosus (SLE) and in human immune cells, according to a new Spanish study. The findings suggest future use in SLE treatment.

The research, “Virgin olive oil and its phenol fraction modulate monocyte/macrophage functionality: a potential therapeutic strategy in the treatment of systemic lupus erythematosus,” was published in the British Journal of Nutrition.

Lupus Overlap in Scleroderma Patients Does Not Seem to Affect Survival

Lupus Overlap in Scleroderma Patients Does Not Seem to Affect Survival

Patients with both scleroderma and systemic lupus erythematosus (SLE) are younger at diagnosis, are more often women, and have less skin manifestations, but most importantly, show similar survival rates as those without lupus, according to a study.

The study, “Epidemiology and Survival of Systemic Sclerosis-Systemic Lupus Erythematosus Overlap Syndrome,” was published in The Journal of Rheumatology.