USA

Role of gut microbiota studied in pregnant women with lupus

Role of gut microbiota studied in pregnant women with lupus

A new study shows that pregnancy and breastfeeding could change the way the body reacts to conventional lupus treatment in women due to imbalances in the gut bacterial community, or dysbiosis. The research was undertaken to understand the higher risk of severe flares and help women with lupus experience healthy pregnancies and successful outcomes, by improving therapeutic approaches.

Researchers Identify Genetic Marker for Lupus in African American Women

Researchers Identify Genetic Marker for Lupus in African American Women

A new study published in the journal Arthritis & Rheumatology finds there may be a genetic explanation for the development of systemic lupus erythematosus (SLE) in African American women.

The study, published on August 20, points to epigenetic changes near interferon-regulated genes early in B cell development. These changes are a “hallmark” of SLE development in African American women, the authors wrote.

“We have identified an aberrant epigenetic signature that developed early in B cell development in African American patients. This observation is consistent with recently published work which identified a SLE-specific epigenetic signature present in the resting naïve B cell stage that persists throughout development in a cohort of Africa American females,” wrote the authors who were led by Devin Absher, Ph.D., of the HudsonAlpha Institute for Biotechnology in Alabama.

Epstein-Barr virus may be a possible trigger for the development of lupus

Epstein-Barr virus may be a possible trigger for the development of lupus

Oklahoma Medical Research Foundation (OMRF) scientists have discovered that the Epstein-Barr virus may be a possible trigger for the development of lupus in at-risk individuals.

Scientists have long known lupus has a strong genetic component, but there also must be environmental triggers to activate the disease.

Cognitive and Psychiatric Issues Linked to Autoantibodies in Brain Unique to Lupus Patients, study finds

Cognitive and Psychiatric Issues Linked to Autoantibodies in Brain Unique to Lupus Patients, study finds

Autoantibodies targeting certain regulatory RNAs — molecules that serve as the template for protein production — in the brains of lupus patients are unique to these people and involved in neuropsychiatric symptoms of the disease, a study reports.

The study, “Neuronal BC RNA transport impairments caused by systemic lupus erythematosus autoantibodies,” was published in the Journal of Neuroscience.

Abnormal Blood Pressure Patterns May Predict Cardiovascular Disease in Juvenile-onset SLE

Abnormal Blood Pressure Patterns May Predict Cardiovascular Disease in Juvenile-onset SLE

Abnormal blood pressure patterns during sleep and overall high blood pressure may independently predict cardiovascular disease in patients with juvenile-onset systemic lupus erythematosus(JSLE), according to a recent update on research supported by the Lupus Foundation of America.

Researchers identify key mechanism linked to neuropsychiatric lupus

Researchers identify key mechanism linked to neuropsychiatric lupus

A breakthrough study by a SUNY Downstate Health Sciences University research team has identified a specific antibody target implicated in neuropsychiatric symptoms of lupus. These symptoms, including cognitive impairment, mood disorders, seizures, headaches and psychosis, are among the most prevalent manifestations of the disease and occur in as many as 80% of adults and 95% of children with lupus.

Blood Clotting Proteins Discovered as Biomarkers of Lupus Nephritis

Blood Clotting Proteins Discovered as Biomarkers of Lupus Nephritis

Researchers have discovered that blood clotting proteins in urine can act as biomarkers in patients with systemic lupus erythematosus (SLE), especially those with lupus nephritis.

The team of researchers at the University of Houston found that blood clotting proteins, both the ones that promote blood clotting (prothrombic) and those that disperse them (thrombolytic) are elevated in the urine of patients with lupus nephritis (LN).

Fracture Risk is High in Lupus

Fracture Risk is High in Lupus

In a study published in a recent issue of Arthritis & Rheumatology, investigators found that patients with lupus nephritis were far more likely to break a bone than patients who do not have lupus.

“Patients with lupus nephritis may be at particularly high risk of fracture due to secondary or tertiary hyperparathyroidism and vitamin D deficiency,” said study author Sara Tedeschi, M.D., MPH, a rheumatology fellow at Brigham and Women’s Hospital.

Study Shows Gazyva® May Offer Potential New Treatment for Lupus Nephritis

Study Shows Gazyva® May Offer Potential New Treatment for Lupus Nephritis

The Lupus Research Alliance shared positive topline results from a Phase 2 clinical study of a potential new treatment for proliferative lupus nephritis, the most severe form of kidney damage caused by lupus. Genentech, a member of the Roche Group, reported that at one year their drug Gazyva® (obinutuzumab) helped more patients achieve a complete response to treatment when added to standard of care with either mycophenolate mofetil or mycophenolic acid plus corticosteroids than those receiving standard of care alone.

Microbiome Composition Influences Autoantibody Development in Lupus

Microbiome Composition Influences Autoantibody Development in Lupus

People with lupus produce autoantibodies causing the body to attack itself and promoting inflammation and tissue damage. A new research study divided people with lupus into two cohorts, or groups, so they could identify key differences. One group consisted of first-degree relatives (FDRs) without lupus and healthy people, and their molecular profiles were compared against a second group, which consisted of unrelated people with and without lupus.

Lupus Treatments Can Be Tailored to Patient's Individual Cells

Lupus Treatments Can Be Tailored to Patient's Individual Cells

The kidneys of patients living with systemic lupus erythematosus (SLE) are often under assault, and not all those living with the disease will respond to standard treatment. A new report published in the journal Nature Immunology online May 20 shows how tissue samples from these patients can accurately predict those more likely than not to respond to therapy. SLE is a disease marked by the attack on joints, skin, and kidneys by the body's immune system..

Bone Protein Found to Reflect Lupus Disease Activity and Renal Involvement

Bone Protein Found to Reflect Lupus Disease Activity and Renal Involvement

Osteopontin (OPN) is a protein present in the bone and other tissues. Elevated levels of OPN have been observed in several autoimmune diseases including lupus. Investigators from a group called Systemic Lupus International Collaborating Clinics (SLICC) examined data from 344 people with lupus over the course of five years to determine whether raised OPN is a reliable biomarker for lupus. Specifically, they wanted to know if increased levels of OPN could predict damage; reflect current disease activity; or if increased OPN levels are associated with certain disease phenotypes (characteristics).