In a new study, researchers looked at whether treatments targeting B-cell activating factor (BAFF) have an impact on human B-cells, as previous studies have suggested. B-cells are responsible for creating antibodies, including autoantibodies, and are thought to play a role in the development and progression of autoimmune diseases.
A breakthrough study by a SUNY Downstate Health Sciences University research team has identified a specific antibody target implicated in neuropsychiatric symptoms of lupus. These symptoms, including cognitive impairment, mood disorders, seizures, headaches and psychosis, are among the most prevalent manifestations of the disease and occur in as many as 80% of adults and 95% of children with lupus.
Researchers have discovered that blood clotting proteins in urine can act as biomarkers in patients with systemic lupus erythematosus (SLE), especially those with lupus nephritis.
The team of researchers at the University of Houston found that blood clotting proteins, both the ones that promote blood clotting (prothrombic) and those that disperse them (thrombolytic) are elevated in the urine of patients with lupus nephritis (LN).
Individuals with systemic lupus erythematosus (SLE) who have primary total hip arthroplasty (THA) are at higher risk for implant infection, discharge to an inpatient facility, more expensive hospital bills, and increased blood transfusions than people without SLE, according to a study recently published in Lupus.
In a study published in a recent issue of Arthritis & Rheumatology, investigators found that patients with lupus nephritis were far more likely to break a bone than patients who do not have lupus.
“Patients with lupus nephritis may be at particularly high risk of fracture due to secondary or tertiary hyperparathyroidism and vitamin D deficiency,” said study author Sara Tedeschi, M.D., MPH, a rheumatology fellow at Brigham and Women’s Hospital.
The Lupus Research Alliance shared positive topline results from a Phase 2 clinical study of a potential new treatment for proliferative lupus nephritis, the most severe form of kidney damage caused by lupus. Genentech, a member of the Roche Group, reported that at one year their drug Gazyva® (obinutuzumab) helped more patients achieve a complete response to treatment when added to standard of care with either mycophenolate mofetil or mycophenolic acid plus corticosteroids than those receiving standard of care alone.
Hydroxychloroquine (Plaquenil®) is the most prescribed medication in the treatment of lupus and has numerous benefits including prevention of flares, prolonged survival, and other positive outcomes. Medication non-adherence is reported in up to 80% of people with lupus and is associated with reduced health outcomes.
People with lupus produce autoantibodies causing the body to attack itself and promoting inflammation and tissue damage. A new research study divided people with lupus into two cohorts, or groups, so they could identify key differences. One group consisted of first-degree relatives (FDRs) without lupus and healthy people, and their molecular profiles were compared against a second group, which consisted of unrelated people with and without lupus.
The kidneys of patients living with systemic lupus erythematosus (SLE) are often under assault, and not all those living with the disease will respond to standard treatment. A new report published in the journal Nature Immunology online May 20 shows how tissue samples from these patients can accurately predict those more likely than not to respond to therapy. SLE is a disease marked by the attack on joints, skin, and kidneys by the body's immune system..
Osteopontin (OPN) is a protein present in the bone and other tissues. Elevated levels of OPN have been observed in several autoimmune diseases including lupus. Investigators from a group called Systemic Lupus International Collaborating Clinics (SLICC) examined data from 344 people with lupus over the course of five years to determine whether raised OPN is a reliable biomarker for lupus. Specifically, they wanted to know if increased levels of OPN could predict damage; reflect current disease activity; or if increased OPN levels are associated with certain disease phenotypes (characteristics).
Adults with lupus who report having had adverse childhood experiences (ACEs), such as abuse, neglect and household challenges, report higher disease activity, depression and poorer overall health compared to those without such experiences, according to a study by researchers at UC San Francisco.
"Our results support the notion that stress in the form of ACEs may be a factor in poor health in systemic lupus, both in disease development and in more severe outcomes," said lead author Kimberly DeQuattro, MD, a clinical fellow in rheumatology at UCSF. "These findings are a call to action to focus efforts on ACE prevention in childhood, as well as clinical and mental health interventions that foster resilience in adulthood."
In a new research survey researchers surveyed people with systemic lupus erythematosus (SLE) about their experiences with diet and their thoughts on diet as a therapeutic option. The study consisted of a 15-question survey focused around diet in people with lupus. The survey was designed to gather important information without being too burdensome for people with lupus to complete.
Pregnant women with lupus are more likely to suffer complications than those who don’t. Lupus Research Alliance Scientific Advisory Board members Dr. Virginia Pascual, Professor at Weill Cornell Medicine; and Dr. Jane Salmon, Collette Kean Research Professor at Hospital for Special Surgery, and their colleagues asked if testing the blood, of pregnant women with lupus, using advanced technologies could identify, early in pregnancy, lupus patients at high risk for complications.
A 20-year study of women with lupus has found strong evidence that depression increases a person’s risk of developing lupus. That insight casts doubt on the generally accepted belief that depression is simply a by-product of having lupus. If depression is the chicken and lupus is the egg, the researchers found that the chicken could come first.
A large international study has probed the causes of lupus-related psychosis—a serious condition marked by delusions and hallucinations. Dr. John Hanly and his co-authors at research centers across several continents found that lupus psychosis (LP) is quite rare, affecting only 1.5 percent of people with lupus. They also observed that the condition tends to occur more often in the first few years after a diagnosis with lupus and is more frequent among male patients and patients of African descent.