Transplantation of Placenta Cells May Halt Inflammation in Lupus Patients

The transplantation of human placental cells was found to suppress immune and inflammatory responses in a mouse model of systemic lupus erythematosus (SLE), suggesting a potential new therapeutic strategy for lupus, a study shows.

The study, “Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto’s thyroiditis and Systemic lupus erythematosus,” was published in the journal Cytotherapy.

Among these, immunoglobulin G (IgG) antibodies against double-stranded DNA — anti-dsDNA antibodies — are one the most common autoantibodies produced in lupus, and are associated with disease activity and development.

Stem cell therapy has been investigated as a potential treatment for autoimmune diseases because these cells are able to self-renew and to reconstitute almost all types of cells in the body, which could help patients recover from their disease-causing injuries.

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