Many years ago (and more recently) we have looked at the pill in our lupus patients and have found that in general there are no major problems, especially with the mini pill. A small group of patients with antiphospholipid antibody (or anticardiolipin antibody) have more of a clotting tendency and obviously these patients present a totally different problem. In these patients oestrogen containing pills should be avoided.
The current view on this has changed over recent years in the light of two studies. Both studies suggest that providing the woman does not have antiphospholipid antibodies, the low-dose combined oral contraceptive should not significantly increase the risk of a lupus flare. In the presence of antiphospholipid antibodies ("sticky blood"), there is an increased risk of blood clots with the combined oral contraceptive. Progesterone is generally OK in APS patients. The Mirena Coil is also generally recommended by the Lupus-In-Pregnancy Clinic at Guys Hospital.